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San Francisco Voyage > Itineraries > Panama Canal Cruises

Panama Canal Cruises from San Francisco

Four cruise lines offer cruises from San Francisco through the Panama Canal. The Canal is an engineering marvel and known as eighth wonder of the world. You'll pass through massive locks that lift or lower the ship. The area is also rich in exotic flora and fauna. The final destinations for these cruises from SF are New York or Florida. See the schedule of departures below.

The Panama Canal is a ship canal that connects the Pacific Ocean to the Atlantic. It is 48 miles long and is a vital route for international trade. Gatun Lake was created to reduce the amount of excavation required for the canal. The lake is 85 feet above sea level so locks at both ends raise and lower ships. See Panama Canal cruises in video.

Panama Canal Cruises from San Francisco 2017

15-day Panama Canal cruise on Princess Cruises. One-way from San Francisco to Fort Lauderdale (Florida). Visit Cabo San Lucas (Mexico), San Juan Del Sur (Nicaragua), Puntarenas (Costa Rica), the Panama Canal, Cartagena (Colombia), and Aruba.
• 2017 departure: March 15.

25-day Panama Canal cruise on P&O Cruises. One-way from San Francisco to Southampton (UK). Visit San Diego (California), Cabo San Lucas (Mexico), Puerto Quetzal (Guatemala), the Panama Canal, Cartagena (Colombia), St Lucia, Barbados, and Ponta Delgada (Azores).
• 2017 departure: March 28.

17-night Panama Canal cruise on Cunard Line. One-way from San Francisco to Fort Lauderdale (Florida). Visit Los Angeles (California), Cabo San Lucas (Mexico), Puerto Quetzal (Guatemala), the Panama Canal, Aruba, and Grand Cayman (Cayman Islands).
• 2017 departure: April 4.

18-night Panama Canal cruise on Regent Seven Seas. One-way from San Francisco to Miami (Florida). Visit Catalina Island (California), Cabo San Lucas (Mexico), Acapulco (Mexico), Puerto Quetzal (Guatemala), Corinto (Nicaragua), Puntarenas (Costa Rica), the Panama Canal, Cartagena (Colombia) and Key West (Florida).
• 2017 departure: July 20.

18-night Panama Canal cruise on Regent Seven Seas. One-way from San Francisco to New York. Visit Cabo San Lucas (Mexico), Acapulco (Mexico), Puerto Quetzal (Guatemala), Corinto (Nicaragua), Puntarenas (Costa Rica), the Panama Canal, Cartagena (Colombia), and Nassau (Bahamas).
• 2017 departure: September 9.

18-day Panama Canal cruise on Oceania Cruises. One-way from San Francisco to Miami (Florida). Visit San Diego (California), Cabo San Lucas (Mexico), Acapulco (Mexico), Puerto Quetzal (Guatemala), San Juan Del Sur (Nicaragua), Puntarenas (Costa Rica), Colon (Panama), the Panama Canal, Cartagena (Colombia), and Key West (Florida).
• 2017 departure: September 20.

15-night Panama Canal cruise on Celebrity Cruises. One-way from San Francisco to Fort Lauderdale (Florida). Visit Cabo San Lucas (Mexico), Puerto Vallarta (Mexico), Puerto Quetzal (Guatemala), Puntarenas (Costa Rica), the Panama Canal, Colon (Panama), and Cartagena (Colombia).
• 2017 departure: October 9.

16-day Panama Canal cruise on Holland America Line. One-way from San Francisco to Fort Lauderdale (Florida). Visit Puerto Vallarta (Mexico), Puerto Chiapas (Mexico), Puerto Quetzal (Guatemala), Corinto (Nicaragua), Puerto Caldera (Costa Rica), the Panama Canal, and Cartagena (Colombia).
• 2017 departure: October 20.

15-day Panama Canal cruise on Princess Cruises. One-way from San Francisco to Fort Lauderdale (Florida). Visit Cabo San Lucas (Mexico), San Juan Del Sur (Nicaragua), Puntarenas (Costa Rica), the Panama Canal, Cartagena (Colombia), and Aruba.
• 2017 departure: October 27.

Panama Canal Cruises from San Francisco 2018

15-day Panama Canal cruise on Princess Cruises. One-way from San Francisco to Fort Lauderdale (Florida). Visit Cabo San Lucas (Mexico), San Juan Del Sur (Nicaragua), Puntarenas (Costa Rica), the Panama Canal, Cartagena (Colombia) and Aruba.
• 2018 departure: March 6.

20-day Panama Canal cruise on Crystal Cruises. One-way from San Francisco to New York. Visit Cabo San Lucas (Mexico), Puerto Chiapas (Mexico), Puerto Quetzal (Guatemala), San Juan del Sur (Nicaragua), Caldera (Costa Rica), the Panama Canal, Cartagena (Colombia), Bimini (Bahamas) and Charleston (South Carolina).
• 2018 departure: August 10.

18-night Panama Canal cruise on Regent Seven Seas. One-way from San Francisco to Miami (Florida). Visit Los Angeles (California), Catalina Island (California), Cabo San Lucas (Mexico), Acapulco (Mexico), Puerto Quetzal (Guatemala), Corinto (Nicaragua), Puntarenas (Costa Rica), the Panama Canal, Cartagena (Colombia) and Grand Cayman (Cayman Islands).
• 2018 departure: September 22.

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